International journal of endocrinology.

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There are 2A and 2B subtypes of type 2 APS. The most common variant of type 2 APS is Schmidt's syndrome (subtype 2A), in which there is adrenal insufficiency associated with autoimmune thyroiditis. Carpenter's syndrome, or subtype 2B, is characterized by a combination of adrenal insufficiency and type 1 diabetes. In the presence of Zanaflex syndrome, adrenal insufficiency is combined simultaneously with autoimmune thyroiditis and type 1 diabetes.

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APS type 2 (APS-2) is characterized by damage to the endocrine glands with the development of adrenal insufficiency (primary hypocorticism), autoimmune thyroiditis, and type 1 diabetes.

Autoimmune polyendocrine syndrome type 1.

These manifestations often accompany primary hypogonadism, myasthenia gravis, vitiligo, alopecia, autoimmune hepatitis, chronic atrophic gastritis, pernicious anemia, hypophysitis. Type 2 APS may also include autoimmune thrombocytopenic purpura, idiopathic diabetes insipidus with autoantibodies to vasopressin-producing cells, isolated adrenocorticoid hormone deficiency, pituitary tumors, scleroderma, etc.

Autoimmune polyendocrine syndrome type 3.

Primary endocrine autoimmune disease Additional endocrine autoimmune disease Other autoimmune diseases. Addison's disease, or type 1 diabetes mellitus, or others (not including autoimmune thyroiditis) in combination with hypogonadism in addition Chronic autoimmune gastritis. hypophysitis, neurohypophysitis Pernicious anemia.

other diseases (which do not include autoimmune thyroiditis; hypoparathyroidism, CD-1 with the main syndrome - Addison's disease) Celiac disease.

one of Tizanidine endocrine diseases, except for autoimmune thyroid diseases) other autoimmune diseases of the endocrine system. The combination of two or more autoimmune diseases of the non-endocrine system should be attributed to the groups of polyimmune diseases, multiple autoimmune syndromes.

Analyzing all of the above, it can be noted that in the identified four types of APS, a number of common features characteristic of autoimmune diseases can be seen. First of all, it is necessary to indicate the presence in all patients of autoantibodies to antigens that correlate with the clinical manifestations of diseases of various endocrine systems.organs that are part of the APS (Table 4). It should be noted that these antibodies may appear much earlier than the development of clinical symptoms of the corresponding diseases. Periodic testing of them is advisable in all patients with the presence of at least one autoimmune disease in order to determine the risk of clinical manifestations of other, new autoimmune diseases.

Below is a comparative description of autoimmune polyendocrine syndromes (Table 5). Among adults with types 2 and 3 APS, the disease occurs predominantly in middle-aged women. APS type 1 is characterized by the manifestation of symptoms in childhood, men are more likely to get sick. At the same time, it should be noted that most types of APS have a proven or suspected polygenic type of inheritance, in some cases with incomplete penetrance.

However, APS type 1 has a monogenic, autosomal recessive mode of inheritance, in which there is a defect in the AIRE gene on the 21st chromosome. Separate studies in a number of patients with type 2 APS revealed abnormalities in the 6th chromosome.

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The exact localization of gene lesions for APS types 3 and 4 has not yet been found. Most of the syndromes have been shown to be associated with HLA alloantigens. Mandatory endocrine syndromes for APS type 1 are autoimmune adrenal insufficiency, hypoparathyroidism, for APS type 2 - autoimmune adrenal insufficiency, autoimmune thyroiditis and / or type 1 diabetes, for APS type 3 - autoimmune thyroiditis and other diseases endocrine organs (except for adrenal insufficiency), for APS type 4 - adrenal insufficiency, type 1 diabetes and other diseases of the endocrine organs.

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It should be noted that among the non-endocrine components, a mandatory symptom of type 1 APS is candidiasis-ectodermal dystrophy. Other autoimmune diseases that are part of almost all types of APS are, as a rule, vitiligo, alopecia, vasculitis, gastritis, hepatitis, intestinal dysfunction, pernicious anemia, malabsorption syndrome, anti-phospholipid syndrome, myasthenia gravis, systemic red lupus, rheumatoid arthritis, Sjögren's syndrome, scleroderma, etc.

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Avtoshunt psshendokrint syndrome is an urgent problem today! medicine, osyulki to take revenge on their own development of autoimmune endocrinopathy in one of the same cases, which are associated with autoimmune non-endocrine pathology.

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In a glance, a random description of some of the autoshunny zhshendokrinnyh syndromes was given, as well as the current dates of the schodo!x, diagnostics and falsehood. Autoimmune pathologies occur due to disorders in the body, which can be provoked by a number of factors. Most often, it is based on hereditary predisposition. Immune cells, instead of foreign agents, begin to attack the tissues of various organs.

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Often such a pathological process occurs in the thyroid gland and joints. The necessary substances do not have time to make up for the losses received from the destructive effects of Zanaflex own immune system. To provoke such violations in the body can: harmful working conditions; viral and bacterial infections; genetic mutations during fetal development.

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Autoimmune processes in the body are manifested in the form of: hair loss; inflammatory process in the joints, gastrointestinal tract and thyroid gland; arterial thrombosis; numerous miscarriages; pain in the joints; weaknesses; skin itching; enlargement of the affected organ; menstrual irregularities; pain in the abdomen; digestive disorders; deterioration of Zanaflex 2mg pills condition; weight changes; urination disorders; trophic ulcers; increased appetite; mood changes; mental disorders; convulsions and trembling of the limbs.

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Autoimmune disorders provoke pallor, allergic reactions to cold, as well as cardiovascular pathologies.

The most common autoimmune diseases, the causes of which are similar: Alopecia areata - baldness occurs as the immune system attacks the hair follicles. Autoimmune hepatitis - inflammation of the liver occurs, as its cells fall under the aggressive influence of T-lymphocytes. There is a change in skin color to yellow, the causative organ increases in size.

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Celiac disease is gluten intolerance. At the same time, the body responds to the use of cereals with a violent reaction in the form of nausea, vomiting, diarrhea, flatulence and pain in the stomach. Type 1 diabetes - the immune system attacks tizanidine that produce insulin. With the development of this disease, a person is constantly accompanied by thirst, increased fatigue, blurred vision, etc. Graves' disease is accompanied by increased production of thyroid hormones.

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In this case, symptoms such as emotional instability, hand trembling, insomnia, and disruptions in the menstrual cycle occur. An increase in body temperature and a decrease in body weight may occur. Hashimoto's disease - develops as a result of a decrease in the production of thyroid hormones. At the same time, the personage is accompanied by constant fatigue, constipation, sensitivity to low temperatures, etc.

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As the disease progresses, paralysis may develop.

Julian-Barré syndrome - manifests itself in the form of a lesion of the nerve bundle connecting the spinal cord and brain. Hemolytic anemia - the immune system destroys red blood cells, causing tissues to suffer from hypoxia. Idiopathic purpura - the destruction of Zanaflex occurs, as a result of which the blood clotting ability suffers. There is an increased risk of bleeding, prolonged and heavy menstruation and bruising. Inflammatory bowel disease is Crohn's disease or ulcerative colitis.

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Immune cells infect the mucous membrane, provoking the appearance of an ulcer that occurs with bleeding, pain, weight loss, and other disorders.

Inflammatory myopathy - there is a lesion of the muscular system. The person experiences weakness and feels unsatisfactory. Multiple sclerosis - own immune cells affect the nerve sheath. At the same time, coordination of movements is disturbed, problems with speech may occur. Biliary cirrhosis - destruction of the liver and bile ducts. A yellow tint of the skin appears, itching, nausea, and other digestive disorders. Myasthenia - the affected area includes nerves and muscles.

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A person constantly feels weak, any movement is difficult.

Psoriasis - destruction of skin cells occurs, as a result, the layers of the epidermis are distributed incorrectly. Rheumatoid arthritis is a systemic autoimmune disease. The body's defenses attack the lining of the joints. The disease is accompanied by discomfort during movement, inflammatory processes. Scleroderma is an abnormal growth of connective tissue. Vitiligo - the cells that produce melanin are destroyed.

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In this case, the skin is colored unevenly.

Systemic lupus erythematosus - the affected area includes the joints, heart, lungs, skin and kidneys. The disease is extremely difficult. Sjögren's syndrome - the salivary and lacrimal glands are affected by the immune system. Antiphospholipid syndrome - damage to the lining of blood vessels, veins and arteries.

SUZANNE

Until now, they remain an unsolved mystery for modern science.

Their essence lies in the counteraction of the immune cells of the body to its own cells and tissues, from which human organs are formed. The main reason for this failure are various systemic disorders in the body, as a result of which antigens are formed. A natural reaction to these processes is an increased production of leukocytes, which are responsible for devouring foreign bodies.

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Classification of autoimmune diseases.

Disorders caused by a violation of the histohematological barrier (for example, if sperm enters an unintended cavity, the body will respond with the production of antibodies - diffuse infiltration, encephalomyelitis, pancreatitis, endophthalmitis, etc.);

The second group arises as a result of the transformation of body tissues under physical, chemical or viral influence.

The cells of the body undergo deep metamorphoses, as a result of which they are perceived as alien. Sometimes in the tissues of the epidermis there is a concentration of antigens that have entered the body from the outside, or exoantigens (drugs or bacteria, viruses). The reaction of the body will be directed at them, but in this case, damage will occur to cells that retain antigenic complexes on their membranes. In some cases, interaction with viruses leads to the formation of antigens with hybrid properties, which can cause damage to the central nervous system;

 

The fourth type, most likely, is generated by genetic abnormalities or the influence of adverse environmental factors, leading to rapid mutations of immune cells (lymphocytes), manifested in the form of lupus erythematosus.

The third group of tizanidine diseases is associated with the coalescence of body tissues with exoantigens, which causes a natural reaction against the affected areas;

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